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Photoinitiated crosslinked degradable copolymer networks for tissue engineering applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
13108 831 2003 11 PDF Available
Title
Photoinitiated crosslinked degradable copolymer networks for tissue engineering applications
Abstract

Diethylene glycol was used to initiate the ring opening polymerization of d,l-lactide and ε-caprolactone, as well as combinations of the two monomers. Esterification of the oligomer end groups with methacryloyl chloride led to divinyl terminated macromers that were reacted via photoinitiated polymerizations to produce crosslinked networks. The lactic and/or caproic acid repeat units can be hydrolyzed under physiological conditions, leading to degradable networks that may be useful for tissue engineering applications. Specifically, methacryloyl terminated poly(lactic acid-co-caproic acid) diethylene glycol based oligomers were prepared and characterized by NMR. The number of ester linkages was kept constant while the ratio of lactic:caproic acid segments was varied. These macromers were then photopolymerized at using a visible light initiating system to produce crosslinked degradable networks. The kinetics of the polymerizations were followed by DSC, and the dynamic mechanical behavior was monitored as a function of temperature to obtain the Tg for each network composition. thick disks were subjected to hydrolytic degradation in an aqueous phosphate buffer solution at a pH=7.4 and 37°C. The changes in the compressive modulus, as well as the % mass loss as a function of time, were recorded. Cellular compatibility was determined by seeding primary rat calverial osteoblast cells onto the disks and characterizing the cell morphology using scanning electron microscopy.

Keywords
Crosslinked degradable networks; Visible light; Mechanical properties; Cellular compatibility; α-hydroxy acid copolymers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 14, June 2003, Pages 2485–2495
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us