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Branched chitosans II: Effects of branching on degradation, protein adsorption and cell growth properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
1312 81 2009 7 PDF Available
Title
Branched chitosans II: Effects of branching on degradation, protein adsorption and cell growth properties
Abstract

The demand for biodegradable implant materials has fueled interest in chitosan as a biomaterial. In previous work, branched chitosans were synthesized and structurally characterized. In this study the biological properties of branched chitosans were explored. Branched chitosans were synthesized by grafting low molecular weight chitosan chains (1.6, 16 and 80 kDa) to high molecular weight (600 kDa) linear chitosans via reductive amination. Films of the branched materials were evaluated with regard to: lysozyme-mediated degradation; protein adsorption; cell adhesion and proliferation. Branched chitosan with a 1.6 kDa branch length exhibited higher degradation rates than either linear or higher branch length materials. Branched chitosans also exhibited reduced adsorption of bovine serum albumin that was more pronounced with thicker films. Branched chitosans supported proliferation of rat endothelial cells, but growth rates were significantly lower than on linear chitosan. The results of this study demonstrate that control of many aspects of chitosan’s physical and biological properties can be achieved by changes in molecular architecture.

Keywords
Branched chitosan films; Biodegradation; Protein adsorption; Cell proliferation; Branched polymers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 5, June 2009, Pages 1575–1581
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us