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Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold

Paper ID Volume ID Publish Year Pages File Format Full-Text
13124 832 2004 8 PDF Available
Title
Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold
Abstract

The aim of this study was to analyse human osteoblast responses to a porous bioactive glass scaffold. It was hypothesised that osteoblasts would attach, proliferate and form mineralised nodules in response to culture on the bioactive glass. As dissolution products are a key feature of bioactive glasses, this was measured by inductively coupled plasma optical emission spectroscopy to determine effects of both the glass surface and ion release. Osteoblasts attached and proliferated on the foams as demonstrated by scanning electron microscopy. Nodule formation was also observed in the pores of the glass and also in conditioned medium containing dissolution products at certain concentrations and these nodules were shown to be mineralised by alizarin red staining. Undiluted dissolution products from the foams however caused significant apoptosis suggesting an ion concentration dependent response.

Keywords
Osteoblast; Bioactive glass; Ion release; Mineralisation; Apoptosis
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Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 11, May 2004, Pages 2039–2046
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us