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Phloroglucinol-based biomimetic adhesives for medical applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
1313 81 2009 6 PDF Available
Title
Phloroglucinol-based biomimetic adhesives for medical applications
Abstract

An adhesive that functions well under moist conditions could facilitate many surgical procedures. In recent studies we designed novel biomimetic glues which mimic the adhesion mechanism of algae, renowned for their remarkable adherence to wet surfaces. Here we extend our previous studies and propose biomimetic formulations, composed of alginate gel and native phloroglucinol, that do not induce cell cytotoxicity. Characterization of the adherence to tissues showed that adhesion was directly related to the mechanical strength of the cross-linked alginate. Therefore the adhesion strength can be altered by changing the source of the calcium cross-linker, the alginate G-content or the molecular weight of the alginate. The adhesion strength was comparable to that of Tisseel™, a commercial tissue adhesive.

Keywords
Biomimetic; Tissue adhesive; Alginate; Phloroglucinol; Biocompatibility
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 5, June 2009, Pages 1582–1587
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us