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Osteoblast response to hydroxyapatite doped with divalent and trivalent cations

Paper ID Volume ID Publish Year Pages File Format Full-Text
13132 832 2004 11 PDF Available
Title
Osteoblast response to hydroxyapatite doped with divalent and trivalent cations
Abstract

The present in vitro study doped hydroxyapatite (HA) with various metal cations (Mg2+, Zn2+, La3+, Y3+, In3+, and Bi3+) in an attempt to enhance properties of HA pertinent to orthopedic and dental applications. X-ray diffraction material characterization indicated that the metal cations may have substituted for calcium in the HA crystal structure and that all of the doped HA formulations were single-phase and crystalline. Scanning electron microscopy analysis revealed a variety of grain sizes, depending on the dopant utilized. Energy-dispersive spectroscopy confirmed that the dopants added during synthesis were present and that all of the HA formulations synthesized were within the defined range of HA phase in the CaO–P2O5–H2O system. Lastly, Bi-doped HA had a slower dissolution rate than either undoped HA or HA doped with other cations when exposed to simulated physiological conditions for 21 days. In terms of cell function, results provided the first evidence that osteoblasts, bone-forming cells, adhered and differentiated (as measured by alkaline phosphatase synthesis) in response to HA doped with trivalent cations (specifically, La3+, Y3+, In3+, Bi3+) at earlier time points than either HA doped with divalent cations (Mg2+, Zn2+) or undoped HA. Of the dopants examined, Bi3+ most enhanced osteoblast long-term calcium-containing mineral deposition. For these reasons, this study revealed for the first time the potential benefits of doping HA with Bi3+ according to criteria critical for bone prosthetic clinical success.

Keywords
Hydroxyapatite; Dopant; Osteoblast; Bismuth; Orthopedic/dental
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Osteoblast response to hydroxyapatite doped with divalent and trivalent cations
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 11, May 2004, Pages 2111–2121
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us