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Macroporous poly(l-lactide) of controlled pore size derived from the annealing of co-continuous polystyrene/poly(l-lactide) blends

Paper ID Volume ID Publish Year Pages File Format Full-Text
13137 832 2004 10 PDF Available
Title
Macroporous poly(l-lactide) of controlled pore size derived from the annealing of co-continuous polystyrene/poly(l-lactide) blends
Abstract

A detailed study on the static annealing of co-continuous polystyrene/poly(l-lactide) (PLLA) blends is presented. The effects of temperature, time at temperature, viscosity of the phases and interfacial modification on the coarsening of the blend are discussed. In this paper, polystyrene and PLLA are blended at compositions of 50/50 and 60/40 to form co-continuous morphologies. These co-continuous morphologies are coarsened under quiescent annealing conditions, and the subsequent removal of the polystyrene phase leaves a macroporous PLLA structure. The microstructure is analyzed using three different techniques: the BET nitrogen adsorption technique, mercury intrusion porosimetry and SEM combined with image analysis. It is shown that static annealing can be used to generate a series of co-continuous networks with controlled pore sizes ranging from 1 to hundreds of microns. A non-linear pore size growth rate is observed for these systems due to the degradation of PLLA and this study indicates that controlled degradation can be used as an additional tool for morphology control. Compatibilized polystyrene/PLLA blends demonstrate significantly reduced coarsening effects due to the reduction of interfacial tension. The coarsening rate of the co-continuous structure was examined in terms of the pore size, R and this growth rate is discussed in terms of a previously proposed coarsening mechanism. This approach is a route towards the preparation of a macroporous PLLA structure with pore sizes in the range required for scaffolds for tissue regeneration.

Keywords
Poly(l-lactide); Macroporous; Polymer blends; Annealing; Co-continuous; Coarsening
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Macroporous poly(l-lactide) of controlled pore size derived from the annealing of co-continuous polystyrene/poly(l-lactide) blends
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 11, May 2004, Pages 2161–2170
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us