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Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement

Paper ID Volume ID Publish Year Pages File Format Full-Text
13141 832 2004 7 PDF Available
Title
Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement
Abstract

Brushite-forming calcium phosphate cements are of great interest as bone replacement materials because they are resorbable in physiological conditions. However, their short setting times, low mechanical strengths and limited injectability limit broad clinical application. In this study, we showed that a significant improvement of these properties of brushite cement could be achieved by the use of sodium citrate or citric acid as setting retardants, such that workable cement pastes with a powder to liquid ratio of up to 5 could be manufactured. The cement used in this study consisted of an equimolar powder mixture of β-tricalcium phosphate and monocalcium phosphate hydrate The use of 500 mm–1 m retardant solutions as liquid phase enabled initial setting times of 8–12 min. Wet compressive strength were found to be in the range between 12–18 MPa after immersion of uncompacted cement samples in serum for 24 h. A further strength improvement to 32 MPa was obtained by compaction of the cement paste during samples preparation. This is significant because high-temperature processes cannot be used to fabricate hydrated calcium phosphate materials. Cement pastes were injectable through a hypodermic needle at a powder to liquid ratio of 3.3 g/ml when a 1 m citric acid was used as liquid phase, thus enabling precise controlled delivery to small defects.

Keywords
Calcium phosphate cement; Brushite; Mechanical properties; Viscosity; Delivery; Injection
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Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 11, May 2004, Pages 2197–2203
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us