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The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
13146 834 2002 8 PDF Available
Title
The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants
Abstract

We addressed the effect of implant thickness, implant porosity, and polyurethane (PU) chemistry on angiogenesis and on the foreign body response in rats. The following materials were implanted subcutaneously for 7 weeks then excised for histologic analysis: a solid PU; a solid polyurethane with silicone and polyethylene oxide (PU-S-PEO); porous expanded polytetrafluoroethylene (ePTFE); and porous polyvinyl alcohol sponge (PVA). Two thicknesses of PU-S-PEO were compared: 300 μm (thin) and 2000 μm (thick).Foreign body capsule (FBC) thickness was much less in PU-S-PEO implants than in PU implants. In addition, FBC were thinner in thin implants than in thick implants. FBC was much more dense in solid implants than in porous implants.As compared with solid implants, porous implants (PVA and ePTFE) led to a marked increase in the number of microvessels that developed adjacent to the implant, as observed both with hematoxylin/eosin staining and with an immunohistochemical anti-endothelial stain.We conclude that the polyethylene oxide and silicone moieties in PU reduce the thickness of the subsequent FBC. In addition, thin implants lead to a thin FBC. Porous implants (PVA and ePTFE) cause more angiogenesis than solid implants. These results may have implications for the measurement of blood-derived analytes by biosensors.

Keywords
Angiogenesis; Biomaterials; Implantation; Immunohistochemistry; Polyurethane; Expanded polytetrafluoroethylene; Polyvinyl alcohol
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The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 21, November 2002, Pages 4185–4192
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us