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Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion

Paper ID Volume ID Publish Year Pages File Format Full-Text
13152 834 2002 8 PDF Available
Title
Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion
Abstract

The thermal stability of polyethylene oxide (PEO) in sustained release tablets prepared by hot-melt extrusion was investigated. The weight average molecular weight of the polymer was studied using gel permeation chromatography. The chemical stability of PEO was found to be dependent on both the storage and processing temperature, and the molecular weight of the polymer. Storage of the polymer above its melting point significantly increased polymer degradation, and the degradation process was accelerated as the molecular weight was reduced. The thermal stability of PEO MW=1,000,000 (PEO 1M) in sustained release chlorpheniramine maleate (CPM) tablets prepared by hot-melt extrusion was found to depend on the processing temperature and screw speed. Lower molecular weight PEO MW=100,000 (PEO 100K) was demonstrated to be a suitable processing aid for PEO 1M. Incorporation of PEO 100K reduced degradation of PEO 1M and did not alter the release rate of CPM. Vitamin E, Vitamin E Succinate and Vitamin E TPGS were found to be suitable stabilizers for PEO, however, ascorbic acid was shown to degrade the polymer in solution. Thermal analysis demonstrated that Vitamin E Succinate and Vitamin E TPGS were dispersed at the molecular level in hot-melt extruded tablets. Solubilized Vitamin E Succinate and Vitamin E TPGS suppressed the melting point of the polyethylene oxide. Drug release rates from hot-melt extruded tablets stabilized with antioxidants were found to be dependent on the hydrophilic nature of the antioxidant.

Keywords
Hot-melt extrusion; Extruded tablets; Polyethylene oxide; Stability; Antioxidants; Chlorpheniramine maleate
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Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 21, November 2002, Pages 4241–4248
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us