fulltext.study @t Gmail

Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure

Paper ID Volume ID Publish Year Pages File Format Full-Text
13156 834 2002 10 PDF Available
Title
Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure
Abstract

In order to improve the mechanical strength of hydroxyapatite (HA) ceramics used as osteoimplants and to enhance cellular penetration functionally graded ceramics with a transition in porosity from the surface towards the centre were designed. The multilayer structures were prepared by multiple tape casting based on an aqueous HA slurry containing polybutylmethacrylate (PBMA) spheres with diameters ranging from 100 to 300 μm. After burning out the PBMA, pores of 70–200 μm were generated. The pore-graded laminates were sintered at temperatures between 1250°C and 1450°C. Bending strength of the pore-graded ceramics was approximately 50% higher as compared to HA of the same pore volume fraction but without gradient structure. The materials were tested in vitro for attachment and activity of osteoblast-like MC3T3-E1 cells over a period of 3 weeks. Cells formed confluent layers on the ceramic surface, penetrated into the graded porosity ranging from 100–150 μm to 250–300 μm in size and showed increasing alkaline phosphatase activity over 3 weeks. The results demonstrated initial in vitro cell compatibility of the functionally graded HA materials and their potential as osteoimplants.

Keywords
Ceramics; Hydroxyapatite; Osteoblasts; Functionally graded materials; Tape casting; Porosity
First Page Preview
Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 21, November 2002, Pages 4285–4294
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us