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Comparison of metal concentrations in rat tibia tissues with various metallic implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
13159 835 2004 8 PDF Available
Title
Comparison of metal concentrations in rat tibia tissues with various metallic implants
Abstract

To compare metal concentrations in tibia tissues with various metallic implants, SUS316L stainless steel, Co–Cr–Mo casting alloy, and Ti–6Al–4 V and V-free Ti–15Zr–4Nb–4Ta alloys were implanted into the rat tibia for up to 48 weeks. After the implant was removed from the tibia by decalcification, the tibia tissues near the implant were lyophilized. Then the concentrations of metals in the tibia tissues by microwave acid digestion were determined by inductively coupled plasma-mass spectrometry. Fe concentrations were determined by graphite-furnace atomic absorption spectrometry. The Fe concentration in the tibia tissues with the SUS316L implant was relatively high, and it rapidly increased up to 12 weeks and then decreased thereafter. On the other hand, the Co concentration in the tibia tissues with the Co–Cr–Mo implant was lower, and it increased up to 24 weeks and slightly decreased at 48 weeks. The Ni concentration in the tibia tissues with the SUS316L implant increased up to 6 weeks and then gradually decreased thereafter. The Cr concentration tended to be higher than the Co concentration. This Cr concentration linearly increased up to 12 weeks and then decreased toward 48 weeks in the tibia tissues with the SUS316L or Co–Cr–Mo implant. Minute quantities of Ti, Al and V in the tibia tissues with the Ti–6Al–4 V implant were found. The Ti concentration in the tibia tissues with the Ti–15Zr–4Nb–4Ta implant was lower than that in the tibia tissues with the Ti–6Al–4 V implant. The Zr, Nb and Ta concentrations were also very low. The Ti–15Zr–4Nb–4Ta alloy with its low metal release in vivo is considered advantageous for long-term implants.

Keywords
Rat; Tibia; Metal ion release; Stainless steel; Cobalt–chromium–molybdenum alloy; Titanium alloy
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Comparison of metal concentrations in rat tibia tissues with various metallic implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 28, December 2004, Pages 5913–5920
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us