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The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro

Paper ID Volume ID Publish Year Pages File Format Full-Text
13160 835 2004 7 PDF Available
Title
The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro
Abstract

Hydroxyapatite (HA) is widely used to coat the metal parts of prosthetic implants in order to improve their biocompatibility and as a bone defect filling material. HA has been demonstrated to produce particles at the prosthetic interface that lead to an activation of phagocytic cells that induce a cascade reaction leading to bone resorption and aseptic loosening. Monocytes/macrophages are commonly observed in the interface tissue, and are among the first cells to colonize the inflammatory site where they play a key role in the immune response. IL-18 is a pro-inflammatory cytokine. Monocytes/macrophages were described as IL-18 producing cells. IL-18 works antagonistically to IL-6, which activates osteoclastogenesis. In the present study, we investigated the ability of HA particles to induce the production of active IL-18 by human monocytes according to particle characteristics (size, sintering temperature and shape). Our study demonstrates, for the first time, that HA particles are capable of stimulating the production of the proinflammatory cytokine IL-18 in human monocytes according to their particle characteristics. The expression and the production of IL-18 was modified by the parameter studied. The difference observed between the expression and the production could be explain by the production of ICE. The needle shaped particles induced the larger production of IL-18.

Keywords
IL-18; Hydroyapatite particles; Human monocytes; Physical characteristics
First Page Preview
The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 28, December 2004, Pages 5921–5927
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering