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Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium

Paper ID Volume ID Publish Year Pages File Format Full-Text
13182 838 2002 11 PDF Available
Title
Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium
Abstract

Calcium phosphate coatings containing an antibiotic were produced on titanium alloy (Ti6Al4V) implants using a biomimetic approach. Thin, amorphous calcium phosphate (ACP) coatings were first deposited onto Ti6Al4V plates by immersion in 5 times concentrated simulated body fluid (SBF), for 24 h at 37°C. The ACP-coated implants were then immersed in a supersaturated calcium phosphate (SCP) solution containing 0, 100, 200, 400, 600 or 800 mg/l of tobramycin for 48 h at 37°C. A carbonated hydroxyapatite (CHA) layer, approximately 40 μm thick, was formed. Approximately 3 μg/mg of tobramycin was co-precipitated with the CHA crystals onto titanium alloy plates, using 800 mg/l tobramycin in the coating solution. For comparison, plasma-sprayed calcium phosphate coatings were also immersed in solutions containing 100, 200, 400 or 1000 mg/l of tobramycin for 10, 40 min, or 48 h. A maximum of about 0.3 μg/mg could be adsorbed onto the plasma-sprayed calcium phosphate coating with the comparable concentration of 800 mg/l in solution. The dissolution of coating and release of tobramycin were also measured in vitro using saline solution buffered at pH 5.0 or 7.3 at 37°C. The release rate of tobramycin was faster at pH 7.3 than at pH 5, with 50 and 4 μg/ml/min, respectively. Tobramycin released from the biomimetic-coated plates could inhibit growth of Staphylococcus aureus bacteria. The result of this study, therefore, indicates that the biomimetic CHA coatings containing antibiotics could be used to prevent post-surgical infections in orthopaedic or trauma.

Keywords
Biomimetic hydroxyapatite coating; Precipitation; Simulated body fluid; Antibiotic; Tobramycin
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Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 20, October 2002, Pages 4143–4153
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us