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In vitro degradation of three-dimensional porous poly(d,l-lactide-co-glycolide) scaffolds for tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
13188 840 2004 10 PDF Available
Title
In vitro degradation of three-dimensional porous poly(d,l-lactide-co-glycolide) scaffolds for tissue engineering
Abstract

In vitro degradation behaviors of three-dimensional tissue engineering porous scaffolds made from amorphous poly(d,l-lactide-co-glycolide) with three different formulations have been systematically investigated up to 26 weeks in phosphate buffer saline solution at 37°C. The following properties of the scaffolds were measured as a function of degradation time: dimensions, weight, compressive strength and modulus, polymer molecular weight and its distribution, and pore morphology. Of special interest was the determination of mechanical properties in wet environment. The pH of the PBS media was also detected. According to the characteristic changes of the various properties of porous scaffolds, the degradation process is suggested to be roughly divided into three stages tentatively named as quasi-stable stage, decrease-of-strength stage, loss-of-weight and disruption-of-scaffold stage.

Keywords
Biodegradable polymer; Degradation; Porous scaffold; Tissue engineering; Mechanical property; Poly(d,l-lactide-co-glycolide) (PLGA)
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In vitro degradation of three-dimensional porous poly(d,l-lactide-co-glycolide) scaffolds for tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 27, December 2004, Pages 5821–5830
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us