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The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury

Paper ID Volume ID Publish Year Pages File Format Full-Text
13190 840 2004 8 PDF Available
Title
The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury
Abstract

Strategies to promote axonal extension through a site of injury, including the provision of nervous system growth factors and supportive substrates, produce growth of axons, that is highly random and does not extend past the lesion site and into the host tissue (Brain Res. Bull 57(6) (2002) 833). Physically guiding the linear growth of axons across a site of injury, in addition to providing neurotrophic and/or cellular support, would help to retain the native organization of regenerating axons across the lesion site and into distal host tissue, and would potentially increase the probability of achieving functional recovery. In the present study, a novel procedure was developed for using freeze-dry processing to create nerve guidance scaffolds made from agarose, with uniaxial linear pores. The hydrated scaffolds were soft and flexible, contained linear guidance pores extending through their full length, were stable under physiological conditions without chemical crosslinking, and could be readily loaded with diffusible growth stimulating proteins.

Keywords
Nerve guide; Regeneration; Scaffold; Polymer; Porous; Agarose
First Page Preview
The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 27, December 2004, Pages 5839–5846
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering