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Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules

Paper ID Volume ID Publish Year Pages File Format Full-Text
13191 840 2004 10 PDF Available
Title
Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules
Abstract

Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of l-(lactic acid) and second generation l-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(l-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.

Keywords
Cell adhesion; Polylactic acid; Scaffold; Self-assembly; Surface modification
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Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 27, December 2004, Pages 5847–5856
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us