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Bioinspired mineralization and cell adhesion on surface functionalized poly(vinyl alcohol) films

Paper ID Volume ID Publish Year Pages File Format Full-Text
1320 81 2009 9 PDF Available
Title
Bioinspired mineralization and cell adhesion on surface functionalized poly(vinyl alcohol) films
Abstract

Poly(vinyl alcohol) (PVA) films, when surface functionalized by phosphorylation, induced biomimetic nucleation and growth of calcium phosphate in a simulated physiological environment. The surface phosphorylation on PVA was ensured by attenuated total reflectance infrared spectroscopy. The morphology of the calcium phosphate phase grown on surface-phosphorylated PVA (PPVA) was analysed using scanning electron microscopy coupled with an energy-dispersive X-ray detector. The primary nucleation of calcium phosphate occurs in 3 days and secondary nucleation occurs after 10 days. The energy-dispersive X-ray analysis shows that the Ca/P ratio of the coating increases with time of exposure to the simulated physiological fluid and reaches 1.67 at 10 days. The PPVA supports in vitro cell adhesion and promotes in vitro biomineralization in the presence of cells, evaluated using human osteosarcoma cells.

Keywords
Biomimetic; Calcium phosphate; Cell adhesion; Functionalization
First Page Preview
Bioinspired mineralization and cell adhesion on surface functionalized poly(vinyl alcohol) films
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 5, June 2009, Pages 1647–1655
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering