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The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices

Paper ID Volume ID Publish Year Pages File Format Full-Text
13214 842 2000 16 PDF Available
Title
The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
Abstract

A considerable research has been conducted on drug delivery by biodegradable polymeric devices, following the entry of bioresorbable surgical sutures in the market about two decades ago. Amongst the different classes of biodegradable polymers, the thermoplastic aliphatic poly(esters) like poly(lactide) (PLA), poly(glycolide) (PGA), and especially the copolymer of lactide and glycolide, poly(lactide-co-glycolide) (PLGA) have generated immense interest due to their favorable properties such as good biocompatibility, biodegradability, and mechanical strength. Also, they are easy to formulate into different devices for carrying a variety of drug classes such as vaccines, peptides, proteins, and micromolecules. Also, they have been approved by the Food and Drug Administration (FDA) for drug delivery. This review discusses the various traditional and novel techniques (such as in situ microencapsulation) of preparing various drug loaded PLGA devices, with emphasis on preparing microparticles. Also, certain issues about other related biodegradable polyesters are discussed.

Keywords
Biodegradable; Poly(lactide-co-glycolide) (PLGA); Bioresorbable
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The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 23, 1 December 2000, Pages 2475–2490
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us