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Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates

Paper ID Volume ID Publish Year Pages File Format Full-Text
13216 843 2004 6 PDF Available
Title
Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates
Abstract

Myriad molecular, cellular, and physiological processes underlie the inflammatory and osteolytic processes induced by particles of biomaterials resulting from the wear of implants such as total joint replacement prostheses. The objective this study was to investigate the role that the complement system may be playing in these phenomena. The aim was to evaluate the degree to which particles of selected orthopaedic materials—high density and ultrahigh molecular weight polyethylene, polymethylmethacrylate, and commercially pure titanium—cause the elevation of a key complement molecule, C3a, in an in vitro assay that directly measured the concentration of C3a. The results demonstrated that HDPE particles, at high concentration, are capable of causing the elevation of C3a in the in vitro assay. This finding is discussed in the context of other work and the mechanics of the complement system as it may affect the osteolytic process.

Keywords
Complement system; Biomaterials; Particles; Orthopaedics; Prostheses; Osteolysis
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Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 23, October 2004, Pages 5347–5352
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us