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Changes in fibroblast morphology in response to nano-columns produced by colloidal lithography

Paper ID Volume ID Publish Year Pages File Format Full-Text
13223 843 2004 8 PDF Available
Title
Changes in fibroblast morphology in response to nano-columns produced by colloidal lithography
Abstract

In designing new biomaterials, specific chemical and topographical cues will be important in guiding cell response. Filopodia are actin-driven structures produced by cells and speculated to be involved in cell sensing of the three-dimensional environment. This report quantifies filopodia response to cylindrical nano-columns (100 nm diameter, 160 nm high) produced by colloidal lithography. Also observed were actin cytoskeleton morphology by fluorescence microscopy and filopodia morphology by electron microscopy (scanning and transmission). The results showed that the fibroblasts used produced more filopodia per μm of cell perimeter and that filopodia could often be seen to interact with the cells’ nano-environment. By understanding as to which features evoke spatial reactions in cells, it may be possible to design better biomaterials.

Keywords
Filopodia; Sensing; Nano-environment; Fibroblasts; Biomaterials
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Changes in fibroblast morphology in response to nano-columns produced by colloidal lithography
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 23, October 2004, Pages 5415–5422
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us