The effect of transforming growth factor-β1, released from a bioabsorbable self-reinforced polylactide pin, on a bone defect
Transforming growth factor-beta 1 (TGF-β1)is a polypeptide growth factor which has been shown to increase bone formation in experimental studies. In this study it was combined to a bioabsorbable self-reinforced poly-ld-lactic acid fracture fixation pin. To assess the effect of TGF-β1 on the healing of a bone defect, the pins were implanted in the rat distal femur next to a bone defect filled with a viscose cellulose sponge. The pins used in the study group (13 rats) contained 50 μg of TGF-β1, whereas in the control group of nine rats an identical pin without the growth factor was used. In the histologic examination at 1, 3 and 6 weeks no difference was detected in the amount of bone inside the viscose cellulose sponge between the rats treated with TGF-β1 and those with no added growth factor. At 3 weeks there was more fibroblast-rich mesenchymal tissue inside the viscose cellulose sponge in the rats treated with TGF-β1. In the radiographic examination at 3 weeks there was an increase in the amount of new periosteal bone on the bone defect in the TGF-β1-treated rats.
Journal: Biomaterials - Volume 23, Issue 18, September 2002, Pages 3817–3823