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The effect of adsorbed fibrinogen, fibronectin, von Willebrand factor and vitronectin on the procoagulant state of adherent platelets

Paper ID Volume ID Publish Year Pages File Format Full-Text
13265 847 2000 10 PDF Available
Title
The effect of adsorbed fibrinogen, fibronectin, von Willebrand factor and vitronectin on the procoagulant state of adherent platelets
Abstract

Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the present study we investigated the effect of adsorbed adhesion proteins (fibrinogen (Fg), fibronectin (Fn), von Willebrand factor (vWF) and vitronectin (Vn)) on the procoagulant activity of adherent platelets. Adsorbed Fn, vWF and Fg promoted platelet adhesion in the following order: Fn

Keywords
Platelet adhesion; Procoagulant activity; Thrombin; Fibrinogen; vWF; Fibronectin; Vitronectin
First Page Preview
The effect of adsorbed fibrinogen, fibronectin, von Willebrand factor and vitronectin on the procoagulant state of adherent platelets
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 22, 15 November 2000, Pages 2243–2252
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering