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Polymorphonuclear neutrophil response to hydroxyapatite particles, implication in acute inflammatory reaction

Paper ID Volume ID Publish Year Pages File Format Full-Text
1327 81 2009 8 PDF Available
Title
Polymorphonuclear neutrophil response to hydroxyapatite particles, implication in acute inflammatory reaction
Abstract

Hydroxyapatite (HA) is widely used as a bone substitute or coating biomaterial in bone diseases or prosthesis metal parts. The release of HA particles induces an inflammatory response and, if uncontrolled, could result in implant loss. Among the hallmarks of such inflammatory response is early recruitment of the polymorphonuclear cells (PMNs). The purpose of this work is to investigate the response of PMNs following exposure to HA in terms of secreted mediators. Our study shows that HA particles increase the release of pro-inflammatory mediators such as interleukin-1α, as well as chemotactic factors such as interleukin-8, macrophage inflammatory protein-1α and macrophage inflammatory protein-1β. HA also induces an increase in matrix metalloproteinase 9 expression. Taken together, our data demonstrate for the first time that HA is capable of activating PMNs, a phenomenon that could potentially contribute to the onset of implant-associated inflammation.

Keywords
Inflammation; Hydroxyapatite; Neutrophil; Cytokines
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Polymorphonuclear neutrophil response to hydroxyapatite particles, implication in acute inflammatory reaction
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 5, June 2009, Pages 1708–1715
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us