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RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

Paper ID Volume ID Publish Year Pages File Format Full-Text
13280 848 2003 31 PDF Available
Title
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
Abstract

Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications. This review gives an overview of RGD modified polymers, that have been used for cell adhesion, and provides information about technical aspects of RGD immobilization on polymers. The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.

Keywords
RGD peptide; Integrin; Polymer modification; Cell attachment; Cell behavior; Review
First Page Preview
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 24, November 2003, Pages 4385–4415
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering