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Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity

Paper ID Volume ID Publish Year Pages File Format Full-Text
13290 848 2003 11 PDF Available
Title
Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity
Abstract

Phosphorylcholine (PC)-endcapped oligomer and block co-oligomer were prepared by employing a photoiniferter-based quasi-living polymerization technique. The designed oligomer had a PC polar head group attached to an alkylene chain at one end of the molecule and an oligo(styrene) (oligoST) segment at the other end. In the co-oligomer, an oligo(N,N-dimethylacrylamide) (oligoDMAAm) segment was inserted between both ends of the oligomer mentioned above. Surface coating of these amphiphilic substances, using an appropriate coating procedure, resulted in a very hydrophilic characteristic, suggesting that the oligoST anchored on the substrate and the PC polar head group was exposed to or located on the outer coating layer. Non-cell adhesivity in serum-containing medium was observed, while slightly reduced protein adsorption was observed. Thus, PC-endcapped oligomer and block co-oligomer appear to function as a biocompatible coating.

Keywords
Phosphorylcholine; Block copolymer; Adsorption
First Page Preview
Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 24, November 2003, Pages 4517–4527
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering