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Soft tissue response to microtextured silicone and poly-l-lactic acid implants: fibronectin pre-coating vs. radio-frequency glow discharge treatment

Paper ID Volume ID Publish Year Pages File Format Full-Text
13294 849 2002 9 PDF Available
Title
Soft tissue response to microtextured silicone and poly-l-lactic acid implants: fibronectin pre-coating vs. radio-frequency glow discharge treatment
Abstract

From in vitro studies it is known that a plasma-treatment can enhance cell spreading. Similar effects can be observed after pre-treatment of the surface with a protein coating, to mediate cell adhesion. The aim of the current study was to evaluate the in vivo effects of these surface modifications, in a three-month experiment in a goat model. We made silicone and poly-l-lactic acid implants with double-sided parallel micro-grooves (depth 1.0 μm, width 10.0 μm), a random surface roughness, or a smooth surface. Implants either received a radio-frequency glow discharge (RFGD) treatment, a fibronectin (Fn) pre-coating, or no pre-treatment. Subsequently, they were inserted into subcutaneous pockets created on the flanks of goats for 1, 3 or 12 weeks. Histological analysis showed that a fibrous tissue capsule had formed around all implants. Histomorphometrical analysis was performed on capsule thickness, capsule quality and the implant–tissue interface quality. Fn-treated surfaces showed a considerable early inflammatory reaction. Besides this, RFGD treatment or Fn pre-coating did not further influence any of the measured parameters. In conclusion, pre-treatment of polymer implant surfaces with Fn or RFGD treatment did not significantly influence tissue reaction around implants with micro-grooved, roughened or smooth surfaces.

Keywords
Tissue reaction; Polymers; Fibronectin; RFGD; Micro-grooves
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Soft tissue response to microtextured silicone and poly-l-lactic acid implants: fibronectin pre-coating vs. radio-frequency glow discharge treatment
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 17, September 2002, Pages 3545–3553
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us