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Identification of apolipoprotein A-I as a major adsorbate on biomaterial surfaces after blood or plasma contact

Paper ID Volume ID Publish Year Pages File Format Full-Text
13298 849 2002 5 PDF Available
Title
Identification of apolipoprotein A-I as a major adsorbate on biomaterial surfaces after blood or plasma contact
Abstract

Apolipoprotein A-I is the major protein component of HDL. It is reported in this communication that apo A-I is a significant component of the protein layer adsorbed from blood or plasma to a variety of biomaterial surfaces, including hydrophobic and hydrophilic polymers, liposomes, a heparinized surface, and a polysulfone hemodialyzer membrane. Evidence in support of this conclusion from SDS-PAGE and immunoblots of proteins eluted from the surfaces after blood or plasma contact is presented. Whether the presence of apo A-I on these surfaces results from the uptake of the free protein or HDL particles remains to be determined. It appears that apolipoprotein A-I and/or HDL deposition may be an important effect in blood–biomaterial interactions generally, and one that has been largely overlooked.

Keywords
Apolipoprotein A-I; High-density lipoprotein; Adsorption; Blood–material interactions.
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Identification of apolipoprotein A-I as a major adsorbate on biomaterial surfaces after blood or plasma contact
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 17, September 2002, Pages 3583–3587
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
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