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Tough biodegradable mixed-macromer networks and hydrogels by photo-crosslinking in solution

Paper ID Volume ID Publish Year Pages File Format Full-Text
133 11 2016 9 PDF Available
Title
Tough biodegradable mixed-macromer networks and hydrogels by photo-crosslinking in solution
Abstract

The preparation of polymeric networks that are both tough and biodegradable remains a challenge. Here we show a very straightforward method to produce tough biodegradable networks from low molecular weight macromers for applications such as tissue engineering. Photo-crosslinking combinatorial mixtures of methacrylate-functionalized poly(1,3-trimethylene carbonate) (PTMC), poly(d,l-lactide) (PDLLA), poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) oligomers in propylene carbonate (PC) allowed the preparation of network films with excellent tensile characteristics and resistance to tearing. This method enabled the production of both very tough mixed-macromer elastomers as well as mixed-macromer hydrogels. A mixed-macromer hydrogel prepared from 33 wt.% PTMC, 33 wt.% PCL and 33 wt.% PEG had a very high tearing energy of 0.81 kJ/m2, which is comparable to tearing energies determined for articular cartilage.

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Keywords
Single-macromer networks; Mixed-macromer networks; Photo-crosslinking; Crosslinking in solution; Hydrogels
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Tough biodegradable mixed-macromer networks and hydrogels by photo-crosslinking in solution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 31, February 2016, Pages 80–88
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us