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Effects of Ti ions and particles on neutrophil function and morphology

Paper ID Volume ID Publish Year Pages File Format Full-Text
13317 849 2002 8 PDF Available
Title
Effects of Ti ions and particles on neutrophil function and morphology
Abstract

We compared the cytotoxicity of soluble and particulate titanium (Ti), vanadium (V) and nickel (Ni) by biochemical functional analysis and by microscopic morphology with micro-area elemental analysis in vitro using human neutrophils as probes and in vivo in animals. The biochemical analyses of LDH, superoxide anion, TNF-α and scanning electron microscopy (SEM) showed that Ni in solution destroys the cell membrane of neutrophils, whereas Ti and V in solution stimulate neutrophils and increase the quantity of released superoxide anions. Fine Ti particles (1–3 μm), which smaller than neutrophils (about 5 μm), were phagocytized by the cells and the results were similar in vivo. These results showed that the cytotoxic effect of Ti particles is size dependent, and that they must be smaller than that of cells.The present study demonstrated that the biochemical functional tests are useful for evaluating the biocompatibility of materials.

Keywords
Titanium; Leukocyte; Superoxide; Cytotoxicity
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Effects of Ti ions and particles on neutrophil function and morphology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 17, September 2002, Pages 3757–3764
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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