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Synthesis and cell affinity of functionalized poly(l-lactide-co-β-malic acid) with high molecular weight

Paper ID Volume ID Publish Year Pages File Format Full-Text
13323 850 2004 9 PDF Available
Title
Synthesis and cell affinity of functionalized poly(l-lactide-co-β-malic acid) with high molecular weight
Abstract

A novel functionalized biodegradable poly(l-lactide-co-β-benzyl malolactonate) (p-PLMA) with high molecular weight was synthesized through ring-opening copolymerization. Three p-PLMA copolymers with different β-benzyl malolactonate content were synthesized. The molecular weight (Mw) and tensile strength of the copolymer with 4 mol% β-benzyl malolactonate content were 179,800 and 19.0 MPa respectively, the molecular weight (Mw) and tensile strength of p-PLMA decreased with β-benzyl malolactonate content increasing. The hydrophilicity of the de-protected product: poly(l-lactide-co-β-malic acid) (d-PLMA) increased with malic acid content increasing. The results of 3T3 mice fibroblasts cultivated on d-PLMA films showed that the cell adhesion on d-PLMA was better than that of PLLA and the cell attached efficiency of d-PLMA with 8 mol% malic acid content was the highest. The cells grew well both on the surface and inside of d-PLMA scaffolds. The cell affinity of d-PLMA was better than that of PLLA.

Keywords
Poly(l-lactide-co-β-malic acid); Biodegradable polymer; Cell affinity; Scaffold; Functionalization
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Synthesis and cell affinity of functionalized poly(l-lactide-co-β-malic acid) with high molecular weight
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 22, October 2004, Pages 5239–5247
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us