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Synthesis, characterization and in vitro degradation of a biodegradable elastomer

Paper ID Volume ID Publish Year Pages File Format Full-Text
13325 850 2004 9 PDF Available
Title
Synthesis, characterization and in vitro degradation of a biodegradable elastomer
Abstract

An elastomer was prepared from biodegradable components as a potential biomaterial for drug delivery and tissue engineering applications. The elastomer was synthesized in two steps. First, a star copolymer (SCP) was manufactured via ring opening polymerization of ε-caprolactone (ε-CL) with d,l-lactide using glycerol as initiator and stannous 2-ethylhexanoate as catalyst. This living SCP was further reacted with different ratios of a crosslinking monomer, 2,2-bis(ε-CL-4-yl)-propane in the presence of ε-CL as a solvent and co-monomer. The elastomers had very low glass transitions (−32°C), sol contents ranging from 17% to 37%, and were soft and weak with physical properties similar to those of natural elastomers such as elastin. The physical properties decreased in a logarithmic fashion with time when degraded in phosphate buffered saline, indicative of first-order degradation kinetics. The elastomers degraded relatively slowly, with degradation being incomplete after 12 weeks.

Keywords
Elastomer; Biodegradable; Bis-caprolactone; Starcopolymer
First Page Preview
Synthesis, characterization and in vitro degradation of a biodegradable elastomer
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 22, October 2004, Pages 5261–5269
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering