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Temperature and pH-responsive polymeric composite membranes for controlled delivery of proteins and peptides

Paper ID Volume ID Publish Year Pages File Format Full-Text
13327 850 2004 11 PDF Available
Title
Temperature and pH-responsive polymeric composite membranes for controlled delivery of proteins and peptides
Abstract

This work was focused on the investigation of temperature and pH-responsive polymeric composite membranes and their permeability to proteins and peptides in response to environmental stimuli. The composite membranes were prepared from nanoparticles of poly(N-isopropylacrylamide-co-methacrylic acid) of various NIPAAm:MAA ratios dispersed in a matrix of a hydrophobic polymer. N-Benzoyl-l-tyrosine ethyl ester HCl, momany peptide, Leuprolide, vitamin B12, insulin, and lysozyme were used as model solutes. The morphology of the membranes was examined with SEM and permeation of the solutes was measured using side-by-side diffusion cells at varied temperatures and pH. Permeability of the solutes across the membranes increased with increasing temperature or particle concentration, while decreased with increasing pH and molecular size of the solutes. Membranes containing nanoparticles of more NIPAAm units exhibited higher thermal sensitivity, and those with higher MAA content showed more pH responsiveness, which was in line with the temperature and pH-responsive volume change of the nanoparticles. The change in permeability was quickly detected following the application of the stimuli. These results and partition study using vitamin B12 supported the proposed gel-pore mechanism of solute permeation through these composite membranes.

Keywords
Thermally responsive material; Membrane; Nanoparticle; Controlled drug release; Protein; Peptide
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Temperature and pH-responsive polymeric composite membranes for controlled delivery of proteins and peptides
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 22, October 2004, Pages 5281–5291
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us