fulltext.study @t Gmail

Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects

Paper ID Volume ID Publish Year Pages File Format Full-Text
13334 851 2002 9 PDF Available
Title
Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects
Abstract

An ovine model was used to investigate the in vivo properties of impacted tricalcium phosphate–hydroxyapatite (TCP–HA) aggregates, varying in chemical composition (ratio of TCP to HA) and particle size distribution (8 versus 3 particle size ranges). All pellets were impacted to a standard compactive effort.Eight sheep underwent implantation of pellets in 4 metaphyseal defects in both rear limbs. Treatment groups consisted of: (1) allograft (clinical control), (2) 50/50 allograft/80% HA/20% TCP in 8 particle size ranges, (3) 50/50 allograft/80% TCP/20% HA in 8 sizes and (4) 50/50 allograft/80% HA/20% TCP in only 3 sizes of particles. Healing of defects was evaluated at 14 weeks with computed tomography, histology and histomorphometry. The computer tomography (CT) density measured in all defects containing synthetic agents was higher than in defects filled with allograft alone (p<0.01). Defects containing 8 sizes of 80% HA/20% TCP granules (group 2) achieved lower histological scores and contained less bone than the clinical control (p<0.05), whereas groups 3 and 4 did not differ from the control. Although all synthetic agents were osteoconductive, our results suggest that increasing the ratio of TCP over HA and limiting the number of particle size ranges to 3 instead of 8 improve the performance of impacted aggregates as graft expanders. Evaluation under loading conditions of morsellised allograft expanded with 80% TCP/20% HA (BoneSave®) in 3 particle size ranges is warranted.

Keywords
Impaction grafting; Revision hip arthroplasty; Tricalcium phosphate; Hydroxyapatite
First Page Preview
Impaction grafting with morsellised allograft and tricalcium phosphate–hydroxyapatite: incorporation within ovine metaphyseal bone defects
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 16, August 2002, Pages 3309–3317
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us