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A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release

Paper ID Volume ID Publish Year Pages File Format Full-Text
13349 851 2002 6 PDF Available
Title
A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release
Abstract

This study is aimed at the development of a method to fabricate porous spherical hydroxyapatite (HA) granules, which can be impregnated with a drug. These drug-loaded particles can be used as a system for targeted and time-controlled drug delivery, e.g. in bone surgery. The method to produce porous granules is based on liquids immiscibility effect. A suspension of HA powder in aqueous solution of gelatin and oil as a dispersion media were used. By stirring the mixtures of these immiscible liquids, granules of 50–2000 μm diameter can easily be produced. Dependence of the granules characteristics on the preparation route was studied. In vivo experiments were performed to simulate drug release kinetics from the granules to the blood of rats.

Keywords
Hydroxyapatite; Granules; Drug delivery
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A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 16, August 2002, Pages 3449–3454
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us