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The in vivo performance of a sol–gel glass and a glass-ceramic in the treatment of limited bone defects

Paper ID Volume ID Publish Year Pages File Format Full-Text
13391 853 2004 7 PDF Available
Title
The in vivo performance of a sol–gel glass and a glass-ceramic in the treatment of limited bone defects
Abstract

The in vivo evaluation, in New Zealand rabbits, of a SiO2–P2O5–CaO sol–gel glass and a SiO2–P2O5–CaO–MgO glass-ceramic, both bioactive in Kokubo's simulated body fluid (SBF), is presented. Bone defects, performed in the lateral aspect of distal right femoral epiphysis, 5 mm in diameter and 4 mm in depth, were filled with (i) sol–gel glass disks, (ii) glass-ceramic disks, or (iii) no material (control group). Each group included 8 mature and 8 immature rabbits. A 4-month radiographic study showed good implant stability without axial deviation of extremities in immature animals and periosteal growth and remodelling around and over the bone defect. After sacrifice, the macroscopic study showed healing of bone defects, with bone coating over the implants. The morphometric study showed a more generous bone formation in animals receiving sol–gel glass or glass-ceramic disks than in control group. Histomorphometric study showed an intimate union of the new-formed bone to the implants. This study allows considering both materials as eligible for bone substitution or repair. Their indications could include cavities filling and the coating of implant surfaces. The minimum degradation of glass-ceramic disks suggests its application in locations of load or transmission forces. As specific indication in growth plate surgery, both materials could be used as material of interposition after bony bridges resection.

Keywords
In vivo test; Bioactive glass and glass-ceramic; Bone graft; Bone substitutes; Osseointegration
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The in vivo performance of a sol–gel glass and a glass-ceramic in the treatment of limited bone defects
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 19, August 2004, Pages 4639–4645
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us