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Decrease in particle-induced osteolysis in obese (ob/ob) mice ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
13394 853 2004 7 PDF Available
Title
Decrease in particle-induced osteolysis in obese (ob/ob) mice ☆
Abstract

There may be variability in the susceptibility of different individuals to osteolysis from wear debris, and it is not clear whether some individuals may have a genetic predisposition for a more marked osteolytic response. The purpose of this study in mice was to determine whether genetically determined obesity can alter the response to particulate debris.Polyethylene particles were implanted onto the calvaria of seven wild-type mice and seven obese mice (ob/ob). Calvaria from unimplanted wild-type and obese mice served as controls. Calvaria were harvested after 7 days, stained with toluidine blue and for tartrate-specific alkaline phosphatase, and analyzed by histomorphometry.The osteoclast number per mm total bone perimeter was 8.000±3.464 in wild-type animals with particles and 2.857±1.676 in ob/ob animals with particles (p=0.0002; Fisher's PLSD). Bone resorption was 1.895±0.713 mm/mm2 in wild-type animals with particles and 1.265±0.494 mm/mm2 in ob/ob animals with particles (p=0.0438; Fisher's PLSD).Particles induced a diminished osteolytic response in genetically determined obese mice, suggesting that obesity may have a protective role against particle-induced bone resorption—similar to obesity and osteoporosis. These important new findings may help to stimulate clinical studies which may define criteria to better identify patients at risk to develop particle-induced osteolysis.

Keywords
Osteolysis; Wear debris; Polyethylene; Particulates; Osteoclast
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Decrease in particle-induced osteolysis in obese (ob/ob) mice ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 19, August 2004, Pages 4675–4681
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us