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α-Tricalcium phosphate cement: “in vitro” cytotoxicity

Paper ID Volume ID Publish Year Pages File Format Full-Text
13429 855 2002 8 PDF Available
Title
α-Tricalcium phosphate cement: “in vitro” cytotoxicity
Abstract

Calcium phosphate-based bioceramics have revolutionized orthopedic and dental repair of damaged parts of the bone system. Among these materials, calcium phosphate-based cements, with hydraulic setting, stand out due to their biocompatibility and in situ hardening, which allow easy manipulation and adaptation to the shape and dimensions of bone defects. An investigation was made of the in vitro cytotoxic effect of calcium phosphate cement based on α-tricalcium phosphate, immersed for different lengths of time in simulated body fluid (SBF), based on the ISO-10993 “Biological Evaluation of Medical Devices” standard. The culture medium was Chinese hamster ovary (CHO) cells in contact with diluted cement extracts. The results revealed that the calcium phosphate cement used was cytotoxic and that the material's cytotoxicity decreased the longer the cement was immersed in SBF.

Keywords
Citotoxicity; Calcium phosphate cement; Bioceramic; Biomaterial
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 9, May 2002, Pages 2035–2042
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us