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Controlled release of rhodium (II) carboxylates and their association complexes with cyclodextrins from hydroxyapatite matrix

Paper ID Volume ID Publish Year Pages File Format Full-Text
13444 856 2002 8 PDF Available
Title
Controlled release of rhodium (II) carboxylates and their association complexes with cyclodextrins from hydroxyapatite matrix
Abstract

Preparation and characterization of a controlled release system of rhodium (II) citrate, acetate, propionate, butyrate and their inclusion or association compounds with cyclodextrin (CD) are described. The porous hydroxyapatite (HA) was characterized by X-ray powder pattern diffraction, FTIR and solid state 31P NMR. Scanning electron microscopy and gas adsorption analysis (BET) were also performed. Release profiles of rhodium (II) carboxylates and their inclusion or association compounds from HA matrix were obtained at different drug loadings (5% and 10%). These were reasonably consistent with a diffusion model. This analysis, mainly using rhodium (II) citrate and butyrate, showed that the strategy of using CDs with a HA matrix may offer a useful new method for the controlled release of these compounds, and hence an alternative strategy for the controlled release of chemotherapeutic agents containing toxic metals. This may be a valuable new technique for localized anti-tumour chemotherapy that minimizes the side effects of such agents.

Keywords
Calcium phosphate; Hydroxyapatite; Drug delivery systems; Controlled release; Rhodium (II) carboxylates; Cyclodextrins
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Controlled release of rhodium (II) carboxylates and their association complexes with cyclodextrins from hydroxyapatite matrix
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 12, June 2002, Pages 2519–2526
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us