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Enhanced cell affinity of poly (d,l-lactide) by combining plasma treatment with collagen anchorage

Paper ID Volume ID Publish Year Pages File Format Full-Text
13455 856 2002 8 PDF Available
Title
Enhanced cell affinity of poly (d,l-lactide) by combining plasma treatment with collagen anchorage
Abstract

Surface properties of poly (d,l-lactide) (PDLLA) were modified by combining plasma treatment and collagen modification. The changes of surface properties were characterized by contact angles, surface energy, X-ray photoelectron spectra and scanning electron microscopy. The mouse 3T3 fibroblasts were used as model cells to evaluate the cell affinity of PDLLA before and after modification. Effects of different modification methods including plasma treatment, collagen coating and combining plasma treatment with collagen anchorage were investigated and compared. The results showed that the hydrophilicity and surface-free energy were improved and reduced, respectively, after each modification. Plasma pre-treatment could improve the roughness as it incorporated the polar groups and positively charged groups onto the sample surface; so the plasma pre-treated surface would benefit in anchoring more collagen tightly. As a result, cell affinity of PDLLA modified by combining plasma treatment with collagen anchorage was greatly improved. The modified materials could endure rinsing by PBS, which would facilitate further application when the modified materials were used as cells scaffold in tissue engineering.

Keywords
Cell affinity; Poly (d, l-lactide); Plasma treatment; Collagen; Cells scaffold; Tissue engineering
First Page Preview
Enhanced cell affinity of poly (d,l-lactide) by combining plasma treatment with collagen anchorage
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 12, June 2002, Pages 2607–2614
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering