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Preparation of novel mesoporous carbons for the adsorption of an inflammatory cytokine (IL-1β)

Paper ID Volume ID Publish Year Pages File Format Full-Text
13460 858 2004 8 PDF Available
Title
Preparation of novel mesoporous carbons for the adsorption of an inflammatory cytokine (IL-1β)
Abstract

Mesoporous carbons derived from two types of sulphonated styrene divinylbenzene copolymers (Macronet MN500HS and CT275, Purolite International Ltd) were produced and their adsorptive capacity for the proinflammatory cytokine IL-1β (MW 14.4 kDa) determined. The carbons produced had surface areas from 400 to 1200 m2 g−1 and pore volume between 0.2 and 1.4 cm3 g−1. The mechanical strength of the carbon beads with surface area values up to 800 m2 g−1 were robust. The highest adsorption value of IL-1β was 150 ng g−1 for a mesoporous carbon with surface area around 900 m2 g−1 and pore volume around 1.3 cm3 g−1. However, there was a trade-off between adsorptive capacity and mechanical strength. When used in conjunction with existing treatment modalities, the materials produced have the potential to enhance the removal of uraemic toxins.

Keywords
Activated charcoal; Adsorption; Middle-molecular weight toxins; Sorbents; Heamodialysis
First Page Preview
Preparation of novel mesoporous carbons for the adsorption of an inflammatory cytokine (IL-1β)
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 15, July 2004, Pages 2933–2940
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering