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A rapid temperature-responsive sol–gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel

Paper ID Volume ID Publish Year Pages File Format Full-Text
13468 858 2004 8 PDF Available
Title
A rapid temperature-responsive sol–gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel
Abstract

Poly(N-isopropylacrylamide) (PNIPAAm) was grafted to methylcellulose (MC) with various feeding ratios using ammonium persulfate and N,N,N′,N′-tetramethyl ethylene diamine as an initiator. FTIR results confirm the formation of PNIPAAm-g-MC copolymers. The temperature responsiveness of copolymer gels was investigated by turbidimetry, dynamic contact angle (DCA), differential scanning calorimetry and dynamic mechanical analysis (DMA). The results indicate that PNIPAAm-g-MC hydrogels are strongly temperature responsive. At lower contents of MC, the lower critical solution temperature (LCST) is decreased, whereas further increasing MC contents raises the LCSTs. It is observed that the phase transition of the hydrogels occurs reversibly within 1 min, and near body temperature, a rigid gel can be generated in a certain range of MC content. What is more, the incorporation of MC prevents the syneresis of copolymer hydrogel. DMA measurement reveals that the storage moduli (E′) of the gels increase upon increasing MC contents, and moreover the values of E′ go up markedly above LCST. The copolymer hydrogels hold a promise as a blood vessel barrier by tuning gelation temperature, gelation time and mechanical strength.

Keywords
Poly(N-isopropylacrylamide); Methylcellulose; Temperature responsive; Hydrogel
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A rapid temperature-responsive sol–gel reversible poly(N-isopropylacrylamide)-g-methylcellulose copolymer hydrogel
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 15, July 2004, Pages 3005–3012
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us