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Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain

Paper ID Volume ID Publish Year Pages File Format Full-Text
13475 858 2004 7 PDF Available
Title
Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain
Abstract

It was reported that nanoparticles with polysorbate 80 (Tween 80, T-80) coating represented tools used for delivering drugs to brain. Nevertheless, disputations were once aroused for some complications. Aimed to have a better understanding of the specific role of T-80 coating on nanoparticles and simplify the problem, the direct observation of brain targeting combined with in vivo experiments was carried out in this work using the model nanoparticles (MNPs). The presence of a complex composed by the model loading, T-80 and nanoparticles was found in the preparation of MNPs. The result was further supported by some surface properties of MNPs. Being bound to nanoparticles that were overcoated by T-80 later, was necessary for the loading to be delivered to brain. Partial coverage was enough for T-80 coating to play a specific role in brain targeting. It seemed that brain targeting of nanoparticles was concerned with the interaction between T-80 coating and brain micro-vessel endothelial cells. Therefore, the specific role of T-80 coating on nanoparticles in brain targeting was confirmed.

Keywords
Polylactic acid (PLA); Nanoparticles; Polysorbate 80 (Tween 80,T-80); Brain targeting; Brain micro-vessel endothelial cells (BMECs); Fluorescein isothiocyanate-dextran (FITC-dextran)
First Page Preview
Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 15, July 2004, Pages 3065–3071
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering