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Complement activation by substituted polyacrylamide hydrogels for embolisation and implantation

Paper ID Volume ID Publish Year Pages File Format Full-Text
13501 861 2002 9 PDF Available
Title
Complement activation by substituted polyacrylamide hydrogels for embolisation and implantation
Abstract

An inflammatory reaction has always been observed in vivo around particles used for therapeutic embolisation. Hydrogel microspheres based on Trisacryl®, prepared by polymerisation of N-acryloyl-2-amino-2-(hydroxymethyl)-1,3-propanediol in the presence of a crosslinking agent, are amongst the best materials for such a purpose. The aim of this work was to evaluate in vitro the complement-activating capacity of the OH-bearing Trisacryl® particles either microporous, or macroporous, or partially substituted with carboxylate, or diethylaminoethyl, or sulphonate groups, in order to be able to decrease the inflammatory reaction in vivo. Complement was activated in the presence of Trisacryl®, but about seven times less than in the presence of Sephadex®, despite a quasi-similar density in OH groups, and more than two times less than in the presence of hydroxymethylated polystyrene despite a higher OH density. This demonstrates that not only OH density, but also other features linked to the type of polymeric backbone, are involved in complement activation by OH-bearing polymeric surfaces. The microporous and macroporous particles activated complement at a similar level when crushed and a slight increase was observed on the rough surface of the macroporous microspheres, but the presence of the macropores did not increase complement activation. Concerning the effects of substituting groups on Trisacryl®, a clear decrease in the complement activation has been found only in the presence of sulphonate groups.

Keywords
Embolisation; Microspheres; Substituted polyacrylamides; Complement activation; Porosity; Roughness; Sulphonate; Hydrogels; Hydroxylated polymer surfaces
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Complement activation by substituted polyacrylamide hydrogels for embolisation and implantation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 11, June 2002, Pages 2319–2327
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us