fulltext.study @t Gmail

Novel fluorescent copolyanhydrides as potential visible matrices for drug delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
13503 861 2002 7 PDF Available
Title
Novel fluorescent copolyanhydrides as potential visible matrices for drug delivery
Abstract

Two classes of fluorescent copolyanhydrides were synthesized by melt copolycondensation of the fluorophoric diacid, p-(carboxyethylformamido)benzoic acid (CEFB), with sebacic acid (SA) or N-trimellitylimidoglycine (TMA-gly). Alternate copolyanhydride based on SA and CEFB was also prepared by solution polycondensation of CEFB and sebacoyl chloride. 1H NMR spectra of the copolymers confirm their structures. Fluorescence was observed for all the copolymers, the intensity of which increases with the CEFB fraction. Either blue (ca. 429 nm) or green (ca. 520 nm) light can be emitted from the copolymers with the excitation of UV (356 nm) and visible (470 nm) light, respectively. The polymers were further fabricated to microsphere formulation, which can be clearly visualized by fluorescent microscopy.

Keywords
Polyanhydrides; Intrinsic fluorescence; Fluorescent microscopy; Microspheres
First Page Preview
Novel fluorescent copolyanhydrides as potential visible matrices for drug delivery
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 11, June 2002, Pages 2345–2351
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us