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Biocompatibility of micro- and nanoparticles. Part I: in liver and kidney

Paper ID Volume ID Publish Year Pages File Format Full-Text
13508 861 2002 7 PDF Available
Title
Biocompatibility of micro- and nanoparticles. Part I: in liver and kidney
Abstract

An accidental discovery led us to correlate a pathology of “unknown origin” with the presence of micro- and nano-particles of inorganic nature in the human tissues.Bioptic samples of livers and kidneys affected by cryptogenic granulomas were observed through a new type of electron scanning microscope called environmental scanning electron microscope and X-ray-microanalyzed with an energy dispersive system. All the randomly selected samples showed the presence of inorganic samples, sometimes varying in chemical composition, but consistent in size (larger in the liver, smaller in the kidney).This article illustrates the results obtained on randomly picked samples and proposes our new investigative method as an aid to achieve a medical diagnosis. Two more items are discussed: the possible, until now unexplained, origin of a pathology as deriving from the presence of exogenous particles, so a new word “nano-pathology” was developed and, as a consequence, the relativity of the concept of biocompatibility as depending on the size of the material considered and its local concentration. The implications of the discovery are briefly discussed.

Keywords
Nano-pathology microdebris; Granuloma; Environmental scanning electron microscopy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 11, June 2002, Pages 2381–2387
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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