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Designing a tubular matrix of oriented collagen fibrils for tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
1351 82 2011 9 PDF Available
Title
Designing a tubular matrix of oriented collagen fibrils for tissue engineering
Abstract

A scaffold composed entirely of an extracellular matrix component, such as collagen, with cellular level control would be highly desirable for applications in tissue engineering. In this article we introduce a novel, straightforward flow processing technique that fabricates a small diameter tubular matrix constructed of anisotropic collagen fibrils. Scanning electron microscopy confirmed the uniform alignment of the collagen fibrils and subsequent matrix-induced alignment of human fibroblasts. The uniform alignment of the fibroblasts along the collagen fibrils demonstrated the ability of the aligned fibrils to successfully dictate the directional growth of human fibroblasts through contact guidance. Various non-cytotoxic cross-linking techniques were also applied to the collagen conduit to enhance the mechanical properties. Tensile testing and burst pressure were the two measurements performed to characterize the mechanical integrity of the conduit. Mechanical characterization of the cross-linked collagen conduits identified 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride cross-linking as the most promising technique to reinforce the mechanical properties of native collagen. An oriented conduit of biocompatible material has been fabricated with decent mechanical strength and at a small diameter scale, which is especially applicable in engineering cardiovascular tissues and nerve grafts.

Keywords
Collagen; Conduit; Anisotropic; Contact guidance; Mechanical characterization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 6, June 2011, Pages 2448–2456
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us