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Development of a long-lasting ventricular catheter impregnated with a combination of antibiotics

Paper ID Volume ID Publish Year Pages File Format Full-Text
13559 880 2003 5 PDF Available
Title
Development of a long-lasting ventricular catheter impregnated with a combination of antibiotics
Abstract

A ventricular silicone catheter impregnated with a combination of rifampin and a quinolone was developed in order to prevent ventricular shunt related infections. As model substance for the quinolones we used sparfloxacin, because of its specific physicochemical properties resulting in a quantitative detection also in the presence of a second antibiotic. In our study we focused especially on an optimization of the antibiotic release out of the impregnated catheters in order to develop long lasting devices with a broad antimicrobial spectrum. A release-optimized catheter was tested with an in vitro colonization test and additionally with a method developed to examine the spread of bacteria on a catheter surface. In vitro experiments showed that the impregnated catheters reduce the colonization with Staphylococcus epidermidis for at least 1 year and prevent the spread of bacteria along the catheter surface.

Keywords
Cerebrospinal fluid shunt; Shunt infection; Prevention; Antimicrobial impregnation
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Development of a long-lasting ventricular catheter impregnated with a combination of antibiotics
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 26, November 2003, Pages 4865–4869
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us