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In vitro study of the effect of titanium on Porphyromonas gingivalis in the presence of metronidazole and spiramycin ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
13576 881 2001 6 PDF Available
Title
In vitro study of the effect of titanium on Porphyromonas gingivalis in the presence of metronidazole and spiramycin ☆
Abstract

Septic peri-implantitis is the main clinical complication encountered following the insertion of titanium implants. It may be resistant to conventional antibiotic treatments. Reports in the literature about antibiotic behavior in the presence of titanium remain controversial. They vary from a bacteriostat to a decreased effect of antibiotic. This study examined, in vitro, the viability of Porphyromonas gingivalis, frequently associated with periodontal diseases, in the presence of titanium and antibiotics (spiramycin and metronidazole alone or in combination). Viability of P. gingivalis was determined, versus a standard curve using the Live/dead Baclight Bacteria Viability Kit™ on 96 well microplates. The results of 48 experiments (60 measurements each) were compiled in a database and compared to each other using the χ2p<0.05 test. When used alone, titanium enhanced bacterial growth as the nickel-chrome control. However, when titanium was used in the presence of antibiotics, antibiotics kept their own effects. Even more, titanium was shown to potentialize the effect of metronidazole. The strengthening of effectiveness of metronidazole by titanium may be due to the oxidation potential of the metal. This chemical property could explain the conflicting data reported in the literature.

Keywords
Porphyromonas gingivalis; Metronidazole; Spiramycin; Titanium
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In vitro study of the effect of titanium on Porphyromonas gingivalis in the presence of metronidazole and spiramycin ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 22, 15 November 2001, Pages 3067–3072
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us