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Characterization of poly(l-lactic acid) microspheres loaded with holmium acetylacetonate

Paper ID Volume ID Publish Year Pages File Format Full-Text
13577 881 2001 9 PDF Available
Title
Characterization of poly(l-lactic acid) microspheres loaded with holmium acetylacetonate
Abstract

Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver metastases because of their low density, biodegradability and favourable radiation characteristics. Neutron activated Ho-loaded microspheres showed a surprisingly low release of the relatively small holmium complex. In this paper factors responsible for this behaviour are investigated, in particular by the use of differential scanning calorimetry, scanning electron microscopy, infrared spectroscopy and X-ray diffraction. The holmium complex is soluble in PLLA up to 8% in films and 17% in microspheres. Interactions between carbonyl groups of PLLA, and the Ho-ion in the HoAcAc complex, explain very satisfactorily the high stability of holmium-loaded microspheres.

Keywords
Holmium; PLLA; Acetylacetonate; MDSC; Microspheres; Radio therapy
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Characterization of poly(l-lactic acid) microspheres loaded with holmium acetylacetonate
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 22, 15 November 2001, Pages 3073–3081
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us