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Novel approach to fabricate porous gelatin–siloxane hybrids for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
13587 882 2002 9 PDF Available
Title
Novel approach to fabricate porous gelatin–siloxane hybrids for bone tissue engineering
Abstract

Porous and bioactive gelatin–siloxane hybrids were successfully synthesized by using a combined sol–gel processing, post-gelation soaking, and freeze-drying process to provide a novel kind of materials in the developments and optimization of bone tissue engineering. The pore sizes of the hybrids can be well controlled by varying the freezing temperature. The scaffolds were soaked in a simulated body fluid (SBF) up to 14 days to evaluate the in vitro bioactivity. The Ca2+-containing scaffolds showed in vitro bioactivity as they biomimetically deposited apatite, but the Ca2+-free scaffolds failed. Cytotoxicity and cytocompatibility of those scaffolds and their extracts were monitored by the MC3T3-E1 cell responses, including the cell proliferation and the alkaline phosphatase activity. It was demonstrated that appropriate incorporation of Ca2+ ions stimulated osteoblast proliferation and differentiation in vitro.

Keywords
Gelatin; Siloxane; Scaffold; Lyophilization; Bioactivity; Cell culture
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Novel approach to fabricate porous gelatin–siloxane hybrids for bone tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 24, December 2002, Pages 4765–4773
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us